Best Supplements For Skin Anti-Aging

There are dozens of nutritional supplements available on the market, many of which proclaim to have anti-aging benefits. In reality, very little or no research has been done to support the majority of these supplements. We don’t know if many common “anti-aging” supplements work the same way in people because they have only been examined in animal or cellular studies.

There are no supplements that reverse aging but there is more evidence for some supplements’ potential advantages than for others, and these advantages often only apply to those who have a confirmed vitamin and/or specific supplement deficiency. Let’s examine some of the scientifically proven anti-aging supplements that are most effective at preventing aging symptoms:

Quercetin

This polyphenol from plants is a rejuvenating supplement that might be beneficial for enhancing the immune system. Although the findings are somewhat contradictory, quercetin was linked to lesser sick days from respiratory tract infections and decreased rates of post-exercise illness in some trials. 

To resolve conflicting findings and determine if quercetin can enhance resistance to infection, more clinical research in humans is required.

Coenzyme Q10

The mitochondrial coenzyme Q10 (CoQ10) is a crucial component. With age, CoQ10 levels often decline. Supplementing with CoQ10 is related to a range of potential benefits. It contains anti-inflammatory and antioxidant properties and can enhance mitochondrial activity.

CoQ10 requires further study before its potential effects can be determined, much like those of the other supplements we’ve reviewed thus far. However, it is quite secure.

Resveratrol

Grapes, peanuts, and berries all contain the chemical resveratrol. Resveratrol has demonstrated various impacts on age-related disorders in clinical trials, including:

Cardiovascular disease: Resveratrol may reduce LDL cholesterol as well as other atherosclerosis-related processes.

Inflammation: Resveratrol may lessen inflammation in smokers, who have high levels of both oxidative stress and inflammation.

Neurological conditions: Resveratrol may enhance several Alzheimer’s disease-related indicators. However, that does not imply that it cures or prevents Alzheimer’s.

The heads up: Better trials are required because the majority of resveratrol studies have involved less than 100 participants. Although resveratrol is harmless and well-tolerated at standard doses, there is some worry that it may have harmful consequences at very high concentrations.

Carnitine

Long-chain fatty acids must be transported into cells via the amino acid carnitine. There is proof that carnitine can benefit some important aging markers, particularly cardiovascular disease.

Carnitine was connected to better cardiovascular health, including reduced fasting glucose, cholesterol levels (LDL cholesterol and total cholesterol), and hemoglobin A1c, in one meta-analysis of more than 20 clinical investigations in humans. All of these variables increase the risk of developing heart disease.

Carnitine is a mixed blessing though. Some data suggest that the non-absorbed portions of carnitine are converted by gut bacteria into a substance called trimethylamine N-oxide (TMAO). Cardiovascular disease and atherosclerosis have been linked to TMAO. To fully understand its effects on heart disease, more research is required.

Nicotinamide riboside

Nicotinamide riboside (NR) exhibits some promise for anti-aging effects in mice studies. There have been only a few modest or limited human investigations on NR.

Its most encouraging result is that it raises levels of nicotinamide adenine dinucleotide (NAD, also known as NAD+), a coenzyme. Theoretically, raising NAD levels with NR supplementation could have anti-aging effects because NAD is implicated in repairing DNA and cellular damage.

Additionally, scientists think that NR may benefit cardiovascular diseases, cognitive and brain function, musculoskeletal injuries, and longevity. Further, it might enhance exercise performance.

NR is undoubtedly promising, but we need more details. Furthermore, even at relatively high doses, it is very safe.

Oral supplements of Hyaluronic Acid

Our soft connective tissues, particularly our largest organ—the skin—contain hyaluronan, more commonly known to skincare enthusiasts as hyaluronic acid. Aging, exposure to the sun and air, and dryness can reduce the amount of HA in the skin and its capacity to retain moisture, resulting in wrinkled-appearing, dry skin.

Orally taken HA may help to lessen wrinkles and enhance the general health of the skin. In a 2021 double-blind, placebo-controlled trial, forty healthy Asian men and women, aged 35 to 64, took 120 mg of HA daily for 12 weeks. The results were published in a 2021 Nutrients Journal.

According to the study, the group that consumed HA throughout the course of the trial showed improvements in water retention, skin elasticity, and wrinkles compared to the group that took a placebo. Hyaluronic acids that are given topically are a good substitute for HA that is taken orally.